The Approach of Immunotherapy

Insights From An Oasis of Healing #17

Topic: The Approach of Immunotherapy by Dr Nathan Goodyear.

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This morning I wanted to talk about a really hot topic. It is relatively new in medicine, hyperthermia. Because I think it really differentiates how immunotherapy is approached from a conventional oncology standpoint and then how we approach it from an integrative oncology standpoint. And I think there’s great confusion out there amongst the patients and that’s who we’re supposed to serve. The way conventional oncology approaches immunotherapy, it’s what I call a one for one effect. What they’re doing in a lot of these medications is they’re blocking one thing to try and turn something on. And there’s some good to it, what are called PD-1 inhibitors, PDL-1 inhibitors. PD-1 is Programmed death 1. This is in part the immune system coming to identify a cancer cell and then what happens, really interesting is because of the cancer and the hypoxia and all the environment that causes a cancer that actually causes it to upregulate the expression of proteins, like for example, Programmed death-ligand 1.

So it expresses that on the surface and then a T-cell comes in there to identify it and the cancer cells says, “Oh no, you don’t.” Puts that ligand in there to the receptor, and it goes, “Oh, okay, I’ll move on.” So what they’re doing with these kind of drugs and immunotherapy is really just a modern chemotherapy. It’s a one for one effect. Block this to do this. When we approach immunotherapy, we’re really approaching it kind of a ripple effect. Ripple effect is a phrase that’s given to business, how one series of events can have a significant consequence in places you would never even imagine. So if you ever had been hiking and you get up in the morning and there’s that lake that just crystal clear and calm like a glass table, you take a pebble and you just drop it and it just ripples.

It’ll ripple all across the entire lake if it’s a big enough splash. And so that’s really what we’re approaching immunotherapy as, as it relates to conventional. We’re looking for that ripple. Doesn’t mean we will use the conventional when it’s indicated, but we want the ripple much more. So our goal is when we use hyperthermia and what we call it, Dr. Lodi calls it mitochondrial regeneration therapy. I’d actually add immunotherapy to that. So mitochondrial and immune regeneration therapy, because that’s really what we’re doing in this ripple effect. So our goals with it is number one, we actually want to increase cyclic AMP. Increasing cyclic AMP will actually improve intracellular signaling and they help mitochondria work better. So regenerate the mitochondria, which are the powerhouses of the cell. We want to thus regenerate and recover mitochondria. There are studies that have actually shown mitochondria within cancer cells can actually be recovered. A paradigm shift in how we approach cancer. We need to eliminate immune suppressive agents.

Cancer will actually produce things that actually suppress the immune system’s ability to get in and at it so that it can evade the immune system. And we need to stimulate the already created immune system. I mean, God created this immune system, it’s there. It’s just dysfunctional. Don’t recreate the wheel. Let’s just polish it up. Let’s just get it working better, and that’s really what we’re doing with how we use immune therapy, especially in part with hyperthermia. But of course we use many other things that work in concert together. But I wanted to just highlight that ripple effect because I think that’s really important and I just want to go through all the effects, at least some, that hyperthermia has been shown to do. So this is going to be really kind of a wow effect of what this one therapy can do for the rest of the body.

 

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